王嫣·研究院院长·理事

科研团队 > 骨干人员 > 王嫣·研究院院长·理事

王嫣·研究院院长·理事

北京大学肿瘤医院分子肿瘤学研究室研究员,博士。专注于肿瘤基因组学及临床转化研究。此前供职于分子肿瘤学国家重点实验室(詹启敏院士课题组),参与负责国家重大研发计划项目(2016YFC0904600),国家重点研发项目(2022YFC3400900),并主持国家自然基金项目(81702748),国家自然面上项目(82173152),高精尖学科建设项目(BMU2019GJJXK019),北京协和医学院协和卓越青年科研基金课题(3332015181),双一流学科建设项目等。从事动物模型研究多年,建立了食管鳞癌恶病质模型,进而发现食管鳞癌外泌体高表达的P4HB蛋白能够通过调控磷酸甘油酸脱氢酶,促进肌肉细胞凋亡和骨骼肌降解,参与多种恶性肿瘤恶病质的形成。课题组也发现P4HBX小分子抑制剂CCF642可能逆转应用铂类药物治疗后的肌肉萎缩,相关研究成果向临床的推进有望改善肿瘤患者恶病质的临床干预手段。

代表论文


1. Gao X et al. Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway. J Extracell Vesicles. 2021 Mar;10(5):e12060. 

 

2. Zhang W et al. The chromosome 11q13.3 amplification associated lymph node metastasis is driven by miR-548k through modulating tumor microenvironment. Mol Cancer. 2018 Aug 21;17(1):125.

 

3. Huang L et al. Long noncoding RNA PCAT1, a novel serum-based biomarker, enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma. Cell Death Dis. 2019 Jul 4;10(7):513.

 

4. GADD45G Interacts with E-cadherin to Suppress the Migration and Invasion of Esophageal Squamous Cell Carcinoma.

Li T, Xu L, Teng J, Ma Y, Liu W, Wang Y, Chi X, Shao S, Dong Y, Zhan Q, Liu X.

Dig Dis Sci. 2020 Apr;65(4):1032-1041. doi: 10.1007/s10620-019-05836-8. Epub 2019 Sep 27.

 

5. Wang Y et al. FAT1, a direct transcriptional target of E2F1, suppresses cell proliferation, migration and invasion in esophageal squamous cell carcinoma. Chin J Cancer Res. 2019 Aug;31(4):609-619.

 

6. Guan Z et al. Long non-coding RNA LOC100133669 promotes cell proliferation in oesophageal squamous cell carcinoma. Cell Prolif. 2020 Apr;53(4):e12750.

 

7. Yeerken D et al. PFKP is transcriptionally repressed by BRCA1/ZBRK1 and predicts prognosis in breast cancer.PLoS One. 2020 May 29;15(5):e0233750.

 

8. Chen J et al.Membranous NOX5-derived ROS oxidizes and activates local Src to promote malignancy of tumor cells. Signal Transduct Target Ther. 2020 Aug 14;5(1):139.

 

9. Wang G et al. A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer. Front Oncol. 2020 Oct 16;10:575711.

 

10. Yan T et al. Author Correction: Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma. Nat Commun. 2020 Nov 12;11(1):5870.