代表论文

2022年：

1.Ji F, Zhang J, Liu N, Gu Y, Zhang Y, Huang P, Zhang N, Lin S, Pan R, Meng Z, Feng XH, Roessler S, Zheng X, Ji J#. Blocking hepatocarcinogenesis by a cytochrome P450 family member with female-preferential expression. Gut. 2022 Jan 7. doi: 10.1136/gutjnl-2021-326050. Online ahead of print.

2021年：

1.Fonseca L, Yanga WS, Geerts D, Turkson J, Ji J#, Ramos JW#. RasGRP1 induces autophagy and transformation-associated changes in primary human keratinocytes. Transl Oncol. 14:100880, 2021.

2.Wei X, Zhao L, Ren R, Ji F, Xue S, Zhang J, Liu Z, Ma Z, Wang XW, Wong L, Liu N, Shi J, Guo X, Roessler S, Zheng X, Ji J#. MiR-125b Loss Activated HIF1α/pAKT Loop, Leading to Trans-Arterial Chemoembolization Resistance in Hepatocellular Carcinoma. Hepatology. 73:1381-1398, 2021.

2020年：

1.Gu Y, Ji F, Liu N, Zhao Y, Wei X, Hu S, Jia W, Wang XW, Budhu A, Ji J, Zhao B, Roessler S, Zheng X, Ji J#. J Exp Clin Cancer Res. 39:268, 2020.

2.Huang H, Ren Z, Gao X, Hu X, Zhou Y, Jiang J, Lu H, Yin S, Ji J, Zhou L, Zheng S. Integrated analysis of microbiome and host transcriptome reveals correlations between gut microbiota and clinical outcomes in HBV-related hepatocellular carcinoma. Genome Med. 12: 102, 2020.

3.Loeffler MA, Hu J, Kirchner M, Wei X, Xiao Y, Albrecht T, De La Torre C, Sticht C, Banales JM, Vogel MN, Pathil-Warth A, Mehrabi A, Hoffmann K, Rupp C, Köhler B, Springfeld C, Schirmacher P, Ji J, Roessler S, Goeppert B. miRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR-451a/ATF2 axis.  J Pathol. 252:239-251, 2020.

2019年：

1.Fako V, Martin SP, Pomyen Y, Budhu A, Chaisaingmongkol J, Franck S, Lee JM, Ng IO, Cheung TT, Wei X, Liu N, Ji J, Zhao L, Liu Z, Jia HL, Tang ZY, Qin LX, Kloeckner R, Marquardt J, Greten T, Wang XW. Gene signature predictive of hepatocellular carcinoma patient response to transarterial chemoembolization. Int J Biol Sci. 15:2654-2663, 2019.

2.Gu Y, Wei X, Sun Y, Gao H, Zheng X, Wong LL, Jin L, Liu N, Hernandez H, Peplowska K, Zhao X, Zhan QM, Feng XH, Tang ZY, Ji J#. miR-192-5p silencing by genetic aberrations is a key event in hepatocellular carcinomas with cancer stem cell features. Cancer Research. 79:941-953, 2019.

3.Zhang Q, Xiao M, Gu S, Xu Y, Liu T, Li H, Yu Y, Qin L, Zhu Y, Chen F, Wang Y, Ding C, Wu H, Ji H, Chen Z, Zu Y, Malkoski S, Li Y, Liang T, Ji J, Qin J, Xu P, Zhao B, Shen L, Lin X, Feng XH. LK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions. Nat Cell Biol. 21:179-189, 2019.

2018年：

1.Wu EM, Wong LL, Hernandez BY, Ji JF, Jia W, Kwee SA, Kalathil S. Gender differences in hepatocellular cancer: disparities in nonalcoholic fatty liver disease/steatohepatitis and liver transplantation. Hepatoma Res 4:66, 2018.

2.Ma X, Chen X, Jin Y, Ge W, Wang W, Kong L, Ji J, Guo X, Huang J, Feng XH, Fu J, Zhu S. Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells. Nat Commun. 9:1303, 2018.

2017年：

1.Xie G, Wang X, Zhao A, Yan J, Chen W, Jiang R, Ji J, Huang F, Zhang Y, Lei S, Ge K, Zheng X, Rajani C, Alegado RA, Liu J, Liu P, Nicholson J, Jia W. Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes. Sci Rep. 2017 Mar 27;7:45232. doi: 10.1038/srep45232.

2.Guo X, Zhao Y, Yan H, Yang Y, Shen S, Dai X, Ji X, Ji F, Gong XG, Li L, Bai X, Feng XH, Liang T, Ji J, Chen L, Wang H, Zhao B. Single tumor-initiating cells evade immune clearance by recruiting type II macrophages. Genes Dev. 2017 Feb 1;31(3):247-259. doi: 10.1101/gad.294348.116.

3.Sun Y*, Ji F*, Kumar MR*, Zheng X, Xiao Y, Liu N, Shi J, Wong L, Forgues M, Qin LX, Tang ZY, Zhao X, Wang XW#, Ji J#. Transcriptome integration analysis in hepatocellular carcinoma reveals discordant intronic miRNA-host gene pairs in expression. International Journal of Biological Sciences. Int J Biol Sci. 2017 Nov 1;13(11):1438-1449. doi: 10.7150/ijbs.20836.

4.Xue R, Li J, Bai F, Wang XW, Ji J#, Lu Y#. A Race to uncover a panoramic view of the liver cancer genome. Cancer Biol Med. 2017 In press doi: 10.20892/j.issn.2095-3941. 2017.0112.

5.Wei X, Liu N, Wang XW, Ji J. Genomics Studies in Hepatocellular Carcinoma via Next-Generation Sequencing. In: Precision Molecular Pathology of Liver Cancer. Editor: Chen Liu. Publishers: Springer Nature. (Book Chapter:Chapter 4). 2017 In press 978-3-319-68080-4.

2016年： 

1.Zhao L, Wong LL, Shi X, Ji J.Should Dysplastic Nodules and Regenerative Nodules Be Regarded as Premalignant Lesions and Treated?Hepatology.2016Oct;64(4):1370.doi: 10.1002/hep.28444.

2015年：

1.Lu YY, Xu W, Ji J, Feng D, Sourbier C, Yang Y, Li C, Qu J, Zeng Z, Wang C, Chang X, Chen Y, Mishra A, Xu M, Lee MJ, Trepel J, Linehan WM, Wang XW, Yang Y, Neckers L. Alternative splicing of the cell-fate determinant Numb in hepatocellular carcinoma. Hepatology 2015. doi: 10.1002/hep.27923. 

2.Li D, Kang N, Ji J, Zhan Q. BRCA1 regulates transforming growth factor-β (TGF-β1) signaling through Gadd45a by enhancing the protein stability of Smad4. Mol Oncol. 2015. doi: 10.1016/j.molonc.

3.Ji J#, Zheng X, Forgues M, Yamashita T, Wauthier EL, Reid LM, Wen X, Song Y, Wei JS, Khan J, Thorgeirsson SS, Wang XW#. Identification of microRNAs specific for epithelial cell adhesion molecule-positive tumor cells in hepatocellular carcinoma. Hepatology 62: 829-40, 2015. (#co-corresponding author)

4.Tao J^, Ji J^, Li X^, Wu H, Wang XW, Calvisi DF, Song G, Chen X. Distinct contribution of microRNAs in different oncogene induced liver cancer formation. Oncotarget 6: 6977-6988, 2015. (^co-first author)

2014年及之前：

1.Wong L, Ogihara M, Ji J, Tsai, N. The Changing Characteristics of Hepatocellular Cancer in Hawaii Over Time. American Journal of Surgery 210: 146-152, 2014.

2.Parpart S, Roessler S, Dong F, Rao1 B, Takai A, Ji J, Qin LX, Ye QH, Jia HL, Tang ZY, Wang XW. Modulation of miR-29 Expression by Alpha-fetoprotein is linked to the Hepatocellular Carcinoma Epigenome. Hepatology 60: 872-883, 2014.

3.Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, and Lorenzo PS. Targeted deletion of RasGRP1impairs Skin tumorigenesis. Carcinogenesis 35: 1084-1091, 2014.

4.Ji J#, Yu L, Yu, Z, Forgues M, Uenishi K, Kubo S, Zhou J, Fan J, Tang ZY, Fu S, Zhu H, Jin JG, Sun HC, Wang XW#. Development of a miR-26 Companion Diagnostic Test for Adjuvant Interferon-alpha Therapy in Hepatocellular Carcinoma. International Journal of Biological Sciences 9: 303-312, 2013. (#co-corresponding author)

5.Budhu A, Roessler S, Zhao X, Yu Z, Forgues M, Ji J, Karoly E, Qin LX, Ye QH, Jia HL, Fan J, Sun HC, Tang ZY, Wang XW. Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated with Progression of Hepatocellular Carcinoma and Patient Outcomes. Gastroenterology  144: 1066-1075, 2013.

6. Ji J and Wang XW. Clinical implications of cancer stem cell biology in hepatocellular carcinoma. Seminars in Oncology 39: 461-72, 2012.

7.Ji J, and Wang XW. Identification of cancer stem cell-related microRNAs in hepatocellular carcinoma. In: Liver Stem Cells: Methods and Protocols. Editor: Takahiro Ochiya. Publishers: Human Press. (Chapter 14) 163-75. 2012.

8.Oishi N, Kumar MR, Roessler S, Ji J, Forgues M, Budhu A, Zhao X, Andersen JB, Ye QH, Jia HL, Qin LX, Yamashita T, Woo HG, Kim YJ, Kaneko S, Tang ZY, Thorgeirsson SS, Wang XW. Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of mir-200c and EMT in intrahepatic cholangiocarcinoma. Hepatology 56: 1792-1803, 2012.

9.Roessler S, Long EL, Budhu A, Chen Y, Zhao X, Ji J, Walker R, Jia HL, Ye QH, Qin LX, Tang ZY, He P, Hunter KW, Thorgeirsson SS, Meltzer PS, Wang XW. Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. Gastroenterology 142: 957-966, 2012.

10. Ji J, and Wang XW. MicroRNAs in Hepatocellular Carcinoma. In: MicroRNAs in Cancer Translational Research. Editor: William C.S. Cho. Publishers: Springer. (Chapter 7) 163-188, 2011.

11. Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, Li C, Veenstra TD, Li B, Yu H, Ji J, Wang XW, Park SH, Cha YI, Gius D, and Deng CX. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell 20: 487-499, 2011.

12.Ji J, Yamashita T, Wang XW. Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma.  Cell and Biosciences 1 2011.

13.Ji J, Wu K, Wu M, Zhan Q. p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell lines. Frontiers of Medicine in China 4: 412-418, 2010.

14.Ji J^, Zhao L^, Budhu, A, Forgues M, Jia HL, Qin LX, Ye QH, Yu J, Shi X, Tang ZY, Wang XW. Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma. Journal of Hepatology 52: 690-697, 2010. (co-first author^)

15.Wang XW, Ji J, Budhu A, Sun HC. MicroRNA analysis for outcome prediction in hepatitis B virus-related liver cancer (Author Reply). Gastroenterology 4: 1626-1627. 2010

16.Budhu A, Ji J and Wang XW. The clinical potential of microRNAs. Journal of Hematology and Oncology 3: 37, 2010.

17.Ji J and Wang XW. A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis. (Invited Commentary Article) Journal of Hepatology 53: 974-5, 2010.

18.Ji J and Wang XW. New kids on the block: Diagnostic and prognostic microRNAs in hepatocellular carcinoma. Cancer Biology & Therapy 8: 1686-1693, 2009.

19.Ji J, Wang XW. What is the relationship among microRNA-181, epithelial cell-adhesion molecule (EpCAM) and beta-catenin in hepatic cancer stem cells (Author Reply). Hepatology 50: 2048, 2009.

20. Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW.  MicroRNA expression, survival, and response to interferon in men and women with liver cancer. New England Journal of Medicine 361: 1437-1447, 2009.

21.Ji J, Yamashita T, Budhu A, Forgues M, Jia H, Li C, Deng C, Wauthier E, Reid LM Ye Q, Qin LX, Yang W, Wang HY, Tang ZY, Croce C, Wang XW. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 50: 472-480, 2009.

22.Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, Jia H, Ye Q, Qin LX, Wauthier E, Reid LM, Minato H, Honda M, Kaneko S, Tang ZY, Wang XW. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 136:1012-1024, 2009.

23. Budhu A, Ji J, and Wang XW. The genomics of human hepatocellular carcinoma. In: Hepatocellular Cancer Diagnosis and Treatment, second edition. Editor: B. Carr. Publishers: Humana Press, NY. (Chapter 5) 131-182, 2009.

24.Ji J^, Liu R^, Tong T, Song Y, Jin S, Wu M, Zhan Q. Gadd45a regulates beta-catenin distribution and maintains cell-cell adhesion/contact. Oncogene 26: 6396-6405, 2007. (co-first author^)

25.Ji J, Wu M, Zhan Q. Gadd45a Function in Suppressing Cell Transformation and Tumor Malignancy.  Progress in Biochemistry and Biophysics 33: 1146-1153, 2006.

26.Tong T^, Ji J^, Jin S, Li X, Fan W, Song Y, Wang M, Liu Z, Wu M, Zhan Q. Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria. Mol Cell Biol 25: 4488-4500, 2005. (co-first author^)

27.姬峻芳, 詹启敏，吴旻. Bcl-2与p53之间的相互作用. 医学分子生物学杂志 2005年02期: 102-4.

28.Ji J, Zhao L, Wang X, Zhou C, Ding F, Su L, Zhang C, Mao X, Wu M, Liu Z. Differential Expression of S100 Gene Family in Human Esophageal Squamous Cell Carcinoma. J Cancer Res Clin Oncol 130: 480-486, 2004.

29.Luo A, Kong J, Hu G, Liew CC, Xiong M, Wang X, Ji J, Wang T, Zhi H, Wu M, Liu Z. Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. Oncogene 23: 1291-1299, 2004.

30.姬峻芳，刘芝华，赵立群。S100蛋白家族与肿瘤. 国外医学肿瘤学分册 2002年04期: 261-3.

综述：

1.Gu Y, Zheng X, Ji J. Liver cancer stem cells as a hierarchical society: yes or no? Acta Biochim Biophys Sin (Shanghai) 52: 723-735, 2020.

2.Xue R, Li J, Bai F, Wang X, Ji J#, Lu Y#. A race to uncover a panoramic view of primary liver cancer. Cancer Biol Med. 14:335-340, 2017

3.Ji J and Wang XW. Clinical implications of cancer stem cell biology in hepatocellular carcinoma. Seminars in Oncology 39: 461-72, 2012.

4.Budhu A, Ji J and Wang XW. The clinical potential of microRNAs. Journal ofHematology and Oncology 3: 37, 2010.

5.Ji J and Wang XW. A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis. (Invited Commentary Article) Journal of Hepatology 53: 974-5, 2010.

6.Ji J and Wang XW. New kids on the block: Diagnostic and prognostic microRNAs in hepatocellular carcinoma. Cancer Biology & Therapy 8: 1686-1693, 2009.

7.Ji J, Wu M, Zhan Q. Gadd45a Function in Suppressing Cell Transformation and Tumor Malignancy.  Progress in Biochemistry and Biophysics 33: 1146-1153, 2006.

8.姬峻芳，詹启敏，吴旻。Bcl-2与p53的相互作用。医学分子生物学2: 102-4, 2005.

9.姬峻芳，刘芝华，赵立群。S100蛋白家族与肿瘤。国外医学肿瘤学分册29: 261-3, 2002.